Prevention and treatment of infections in the respiratory and digestive tract caused by Actinobacillus pleuropneumonia (APP), Pasteurella multocida, Haemophilus paragallinarum, Mycoplasma sp., fowl typhoid, Haemophilus parasuis, Streptococcus suis. Also active against enteric diseases triggered by Salmonella spp., E. Coli, Campylobacter sp., Clostridium sp., Lawsonia infracellularis, and Brachyspira spp.
Each 1 kg contain:
Florfenicol 40 g
Excipients 960 g
Florfenicol is a synthetic broad-spectrum antibiotic, which is a derivative of thiamfenicol. It demonstrates effect against Pasteurella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Salmonella spp., Escherichia coli, Proteus spp., Haemophilus spp., Staphylococcus spp., Streptococcus spp., Shigella spp., Klebsiella spp., Enterobacter spp., Aeromonas salmonicida, Campylobacter spp., Edwardsiella ictaluri, Edwardsiella tarda, Flexibacter spp., Yersinia pseudotuberculosis, Vibrio spp., as well as mycoplasmas (Mycoplasma spp.). The mechanism of action is related to inhibition of activity of microbial cell peptidyl transferase, particularly – in the area of 70S ribosomes.
After oral administration florfenicol is well (about 90%) absorbed from digestive tract and distributed in organs and tissues, reaching concentrations of 4-8 μg/g in lungs, heart, pancreatic gland, skeletal muscles, spleen. Relatively high concentrations are found in bile, kidneys, small intestine, urine. Urinary metabolites are composed of florfenicolamine, florfenicol oxamic acid, monochloroflorfenicol. About 64% of florfenicol is biotransformed into florfenicol amine – a metabolite, which is present in liver for the longest period. Half-life period of the drug makes 2.6-3.2 hours on average. It is mostly (up to 50%) eliminated from the body with urine unchanged, the rest of the drug and its metabolites are eliminated with feces.
For the treatment and prevention of respiratory and GI tract infections caused by Florfenicol sensitive microorganisms in pigs, calves, poultry.
Pigs and calves:
- Complex respiratory infection, enzootic pneumonia, APP, pasteurellosis, erysipelas and secondary infections of PRRS.
- Prevention of salmonellosisu; diarrhea caused by E.coli, white, blood or yellow scour, edema, colitis, dysentery.
- Green and white scour, CRD, CCRD, pasteurellosis.
ADMINISTRATION AND DOSAGE
Oral administration via feed
- Curative dose: 2 kg Florfenicol 4% per 1 ton of feed, for 5-7 consecutive days.
- Prophylactic dose: 1 kg Florfenicol 4% per 1 ton of feed, for 3-5 days.
- Curative dose: 1 kg Florfenicol 4% per 1 ton of feed, for 5-7 consecutive days.
- Prophylactic dose: 0.5 kg Florfenicol 4% per 1 ton of feed, for 3-5 consecutive days. Repeat after 2-3 weeks.
Meat: 14 days
Ensure uniform dispersion of enramycin premix in feed by method of multi-stage mixing. Or add to combined feed through a commercially produced vitamin and mineral premix.
Store under dry conditions below 25ºC.
Expiry date is 2 (two) years after date of manufacture.
25 kg bags: Inner lining is made of polyethylene; outer layer is made of 3-ply paper.